Across the Spider-Verse’s Spider-Man 2099 injects himself with a mysterious substance during the movie. Here’s how it ties to Miguel O’Hara’s powers.

WARNING: This article contains SPOILERS for Spider-Man: Across The Spider-Verse.What Spider-Man 2099 injects himself with in Spider-Man: Across the Spider-Verse traces back to Miguel O’Hara’s comic book origins and may help explain his powers. Across the Spider-Verse finally paid off Spider-Man: Into the Spider-Verse’s ending by bringing Miguel O’Hara, Spider-Man 2099, into the story. Spider-Man 2099 may have been one of Across the Spider-Verse’s main characters, but Across the Spider-Verse's ending left a few questions unanswered when it comes to the futuristic Spider-Man.
Across the Spider-Verse jumped right into the action as Spider-Woman and Spider-Man 2099 crashed into Spider-Gwen’s universe to capture the Renaissance Vulture. The Into the Spider-Verse sequel moved arguably faster than the first film, introducing several new characters and universes. One of the mysteries associated with Spider-Man 2099 was the substance Miguel injected himself with, which ties into the character’s origin story.
Spider-Man 2099's Injections Link To His Comic Backstory

Spider-Man: Across the Spider-Verse did not offer too much context on Spider-Man 2009’s injections, yet they link to Miguel O’Hara’s comic book backstory. In Marvel Comics, before he turns into Spider-Man, Miguel becomes addicted to an extremely powerful drug known as Rapture. Rapture, which binds to the user’s DNA, was the reason why Miguel performed a genetic experiment on himself – he wanted to break free of the Rapture addiction. Miguel’s experiment went wrong, and while the Rapture addiction was resolved, he became “half spider” on a molecular level. There are no Spider-Man 2099 injections in the comics, but those could be Across the Spider-Verse’s version of Rapture.
Another option is that Across the Spider-Verse is combining the Rapture addiction storyline with the serum used in the experiment that transformed Miguel into Spider-Man. Perhaps Spider-Man 2099 is still addicted to Rapture in this particular Across The Spider-Verse universe. Another possibility is that the serum that gave Spider-Man 2099 his powers, which in the comics is sort of a Super Soldier serum variation based on Peter Parker's physiology, has now become addictive to Miguel.
Do Spider-Man 2099's Injections Give Him His Powers?

If Across the Spider-Verse’s Spider-Man 2099 powers have the same origin story as his comic book counterpart, then the injections do not give him special abilities. In the comics, Miguel’s powers come from a failed experiment. While a serum was involved, Spider-Man 2099’s origin has nothing to do with injections. That said, Across the Spider-Verse’s Spider-Man 2099 is different from Marvel Comics in a few ways, including parts of his backstory. Therefore, it would be no surprise if Miguel’s transformation into a literal Spider-Man is linked to the injections. Should that be the case, Across the Spider-Verse's Spider-Man 2099 injections might be what give him powers after all.
It is also possible that Spider-Man 2099’s injections help keep Miguel’s DNA stable, thus preventing him from becoming “50% spider.” Miguel O Hara’s spider-like traits, including the fangs and the red eyes, were kept for Across the Spider-Verse. Miguel was even compared to a vampire in Across the Spider-Verse, as he uses his fangs as a weapon quite often. Regardless of the full context behind Spider-Man 2099’s injections, that small Spider-Man: Across the Spider-Verse Easter egg perfectly ties the film's Miguel O’Hara to his Marvel Comics counterpart.
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